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Musculoskeletal injury impacts 50% of people 18 and older and 75% of people over 65. Tendon/ligament injuries (e.g. tennis elbow, golfer's elbow, rotator cuff, Achilles, ACL/MCL tears) make up more than 30% of these injuries.
Tendon/ligament injuries prevent people from working or exercising and are the most common cause for athletes taking extended breaks.
Rapid and complete recovery presents the biggest challenge to returning to pre-injury form — often ending careers (both in sports and physically demanding professional trades).
Surgical repairs offer the fastest remedy but the highest complication rate based on the fibrovascular scar tissue formed rather than natural/normal tendon.
Non-operative approaches (rest, PT, etc.) provide the repair with the least complications but significantly longer recovery times.
Torn and sprained tendons heal through the formation of disorganized collagen fibers resulting in less strength and high re-tear rates.
Current therapeutic strategies do not produce natural tendon/ligament growth and repair but rather they rely on/induce disorganized scarring.
Strong joints and freedom of movement are critical to:
Loss of strength, stability, mobility, or repeated re-tearing significantly impacts:
Collagen accounts for 30% of your body’s protein. It provides structure, support, or strength to your skin, muscles, bones, and connective tissues (tendons and ligaments).
There are two core collagen-based fibrous connective tissues of interest:
Tendons connect muscle to bone.
Ligaments connect bone to bone.
Healthy tendons and ligaments are a complex arrangement of collagen fibers with sparse tendon cells throughout. These cells are responsible for intense procollagen production during initial tendon formation as well as tendon strengthening during weight bearing exercise.
Tendon injury can range from micro tears to partial or full tears. Current therapeutic approaches do not support rebuilding of organized collagen fibers with the strength and resilience of the original tendon.
SNZRpl is the crucial cell density signalling molecule guiding tendon cell proliferation, differentiation and collagen production.
The two factors (a peptide and a phospholipid) create the perfect signalling mechanism to produce all the components of a tendon growth plate (the unique mechanism by which tendons grow and repair).
However, these dormant cells remain highly sensitive to SNZRpl concentrations and tendon remodeling and repair can be produced simply by the raising the concentration of SNZRpl in the local cellular environment.
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