Tendon Research Foundation

Tendon Research FoundationTendon Research FoundationTendon Research Foundation
Home
Tendon Injury & Science
Team

Tendon Research Foundation

Tendon Research FoundationTendon Research FoundationTendon Research Foundation
Home
Tendon Injury & Science
Team
More
  • Home
  • Tendon Injury & Science
  • Team
  • Sign In
  • Create Account

  • My Account
  • Signed in as:

  • filler@godaddy.com


  • My Account
  • Sign out

Signed in as:

filler@godaddy.com

  • Home
  • Tendon Injury & Science
  • Team

Account


  • My Account
  • Sign out


  • Sign In
  • My Account

Tendon & Ligament Injury Facts

Prevalence

Musculoskeletal injury impacts 50% of people 18 and older and 75% of people over 65. Tendon/ligament injuries (e.g. tennis elbow, golfer's elbow, rotator cuff, Achilles, ACL/MCL tears) make up more than 30% of these injuries. 

The Impact

Tendon/ligament injuries prevent people from working or exercising and are the most common cause for athletes taking extended breaks. 

Rapid and complete recovery presents the biggest challenge to returning to pre-injury form  —  often ending careers (both in sports and physically demanding professional trades).  

Current Interventions & Recovery

Surgical repairs offer the fastest remedy but the highest complication rate based on the fibrovascular scar tissue formed rather than natural/normal tendon. 


Non-operative approaches (rest, PT, etc.) provide the repair with the least complications but significantly longer recovery times.

The Challenges

Torn and sprained tendons heal through the formation of disorganized collagen fibers resulting in less strength and high re-tear rates.


Current therapeutic strategies do not produce natural tendon/ligament growth and repair but rather they rely on/induce disorganized scarring.

Quality of Life Costs

Strong joints and freedom of movement are critical to:

  • successful employment in physically demanding professional trades
  • remaining physically active to sustain overall health, especially in the elderly
  • pursuing athletic goals in the amateur and professional arena

Economic Impact

Loss of strength, stability, mobility, or repeated re-tearing significantly impacts:

  • ability to return to physical professions and earn a living
  • sporting performance and potential to transition into professional sports
  • diminished contribution to professional team performance reducing personal and franchise income

The Science of Tendons & Ligaments

Collagen

Healthy Tendons and Ligaments

Healthy Tendons and Ligaments

Collagen accounts for 30% of your body’s protein. It provides structure, support, or strength to your skin, muscles, bones, and connective tissues (tendons and ligaments).  

There are two core collagen-based fibrous connective tissues of interest:

Tendons connect muscle to bone.

Ligaments connect bone to bone.

Learn More

Healthy Tendons and Ligaments

Healthy Tendons and Ligaments

Healthy Tendons and Ligaments

Healthy tendons and ligaments are a complex arrangement of collagen fibers with sparse tendon cells throughout. These cells are responsible for intense procollagen production during initial tendon formation as well as tendon strengthening during weight bearing exercise.

Learn More

Tendon & Ligament Injury

Healthy Tendons and Ligaments

Tendon & Ligament Injury

Tendon injury can range from micro tears to partial or full tears. Current therapeutic approaches do not support rebuilding of organized collagen fibers with the strength and resilience of the original tendon.

Learn MOre

SNZRpl

SNZRpl is the crucial cell density signalling molecule guiding tendon cell proliferation, differentiation and collagen production.  

The two factors (a peptide and a phospholipid) create the perfect signalling mechanism to produce all the components of a tendon growth plate (the unique mechanism by which tendons grow and repair).

  • With high SNZRpl concentrations tendon cells divide and create new cells.  
  • As these cells mature the high SNZRpl concentration elicits collagen production and extrusion into highly organized fibers.
  • As the collagen fibers create space between the cells and thus the SNZRpl concentration decreases, the cells become the dormant cells found in adult tendon.


However, these dormant cells remain highly sensitive to SNZRpl concentrations and tendon remodeling and repair can be produced simply by the raising the concentration of SNZRpl in the local cellular  environment.

Copyright © 2025 Tendon Research Foundation - All Rights Reserved.


This website uses cookies.

We use cookies to analyze website traffic and optimize your website experience. By accepting our use of cookies, your data will be aggregated with all other user data.

Accept